Hemoglobin-Based Oxygen Carrier Mitigates Transfusion-Mediated Pancreas Cancer Progression
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منابع مشابه
hemoglobin-based oxygen carrier for traumatic hemorrhagic shock treatment in a jehovah’s witness
introduction treatment of severe hemorrhagic shock due to acute blood loss from traumatic injuries in a jehovah’s witness (jw) trauma patient is very challenging since hemostatic blood product resuscitation is limited by refusal of the transfusion of allogeneic blood products. case presentation we describe a multifaceted approach to the clinical care of a severely anemic jw trauma patient inclu...
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Transfusable fluids that may be used as alternatives to red blood cell transfusion offer the promise of preserving tissue perfusion and minimizing hypoxic cellular damage, and this promise may soon be fulfilled. Clinical testing of hemoglobin-based oxygen carriers has faced and met challenges involving molecular design, safety, efficacy, and regulatory requirements. Three leading candidates hav...
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Background and Objective Our previous study showed that liver graft injury not only promotes tumor recurrence, but also induces chemoresistance in recurrent HCC after liver transplantation. Recently, we found that the hemoglobin-based oxygen carrier"YQ23" significantly ameliorates hepatic IR injury and prevent tumor recurrence. Here, we intended to explore the novel therapeutic strategy using o...
متن کاملBlood volume and cardiac index in rats after exchange transfusion with hemoglobin-based oxygen carriers.
We have measured plasma volume and cardiac index in rats after 50% isovolemic exchange transfusion with human hemoglobin cross-linked between the alpha-chains with bis(3,5-dibromosalicyl)fumarate (alpha alpha Hb) and with bovine hemoglobin modified with polyethylene glycol (PEGHb). alpha alpha Hb and PEGHb differ in colloid osmotic pressure (23.4 and 118.0 Torr, respectively), oxygen affinity (...
متن کاملControlled safety study of a hemoglobin-based oxygen carrier, DCLHb, in acute ischemic stroke.
BACKGROUND AND PURPOSE Diaspirin cross-linked hemoglobin (DCLHb) is a purified, cell-free human hemoglobin solution. In animal stroke models its use led to a significant reduction in the extent of brain injury. The primary objective of this study was to evaluate the safety of DCLHb in patients with acute ischemic stroke. METHODS DCLHb or saline was administered to 85 patients with acute ische...
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ژورنال
عنوان ژورنال: Annals of Surgical Oncology
سال: 2013
ISSN: 1068-9265,1534-4681
DOI: 10.1245/s10434-012-2842-0